The S&P 500 lost 2.8 percent of its value, and the Nasdaq fell by 3.3. percent.
The Nasdaq composite lost 240 points, or 3.2 percent, to 7,201. The VIX Volatility Index was higher at 20.59 for a gain of 4.15 points or 25.24%.
United States stocks have nosedived amid concerns about trade with China and fears of a weakening economy. In the Treasury market, three-year yields are above five-year ones, foreshadowing the end of Federal Reserve's tightening campaign. The Treasury held auctions for four-week bills at a rate of 2.320% and 52-week bills at a rate of 2.635%. Small-cap stocks were hit hard, with the Russell 2000 Index falling 68.21 points, or 4.4%. The S&P 600 closed at 925.06 for a loss of 44.71 points or -4.61%. Eastern Time. The Dow plunged 730 points, or 2.8 percent, to 25,095, more than erasing its 488-point gain over the previous two trading days.
The Dow fell by as much as 719 points, or 2.8 percent by mid-afternoon Tuesday, for a total drop of 800 points.
The S&P 500 .SPX posted its biggest single-day percentage drop in about two months, giving back some gains from Monday and a week earlier, when the benchmark index tallied its largest weekly percentage gain in almost seven years.
Chipmakers were among the biggest decliners in a technology sector slide.
Homebuilders fell after luxury homebuilder Toll Brothers issued a cautious assessment of the housing market. Ten-year yields are below 3 percent.
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In newly developed "universal cancer test ", the suspect DNA has been added to the water containing tiny gold nanoparticles. Additionally, the research was supported by a National Breast Cancer Foundation grant to advance cancer diagnosis testing.
The Nasdaq is up 255.03 points, or 3.7 percent.
Investors were focused on U.S. Treasury yields, where the benchmark 10-year yield fell to its lowest point since mid-September.
Amid fears of slowing U.S. growth, Dollar General Corp sank 8% after warning that the proposed tariffs on Chinese imports could begin to have a greater impact on its business as well as its customers. Shares also fell in Taiwan and all other regional markets.
Oil prices headed higher ahead of an OPEC meeting on Thursday, where members are expected to agree to cut output in 2019. Benchmark U.S. crude gained 0.6 percent to settle at $53.25 per barrel in NY. Brent crude, the global standard, added 0.9 per cent to $62.22 per barrel in London.
CURRENCY: The dollar gained to 112.95 yen from Wednesday's 112.78 yen. The euro strengthened to $1.1349 from $1.1342. Germany's DAX lost 1.1 per cent, while France's CAC 40 dropped 0.8 per cent. The FTSE 100 index of leading British shares slid 0.6 percent. In Japan, the Nikkei 225 index fell 0.4 percent to 21,946.94.
In Asia early Wednesday benchmarks fell by no more than 1.5 percent, the loss for the Hang Seng index in Hong Kong, which was at 26,860.43 by mid-morning.
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