Hope in Africa as HIV vaccine shows promising results

10 July, 2018, 04:54 | Author: Lillian Steele
  • World AIDS day 3

The achievement was considered to be too small for the drug to go ahead and come into the market as a HIV vaccine.

According to a study in The Lancet, a new HIV vaccine is now being tested and developed, showing promising results thus far.

"These results represent an important milestone".

The near 40-year quest for an Aids vaccine received a hopeful boost on Saturday (July 7) when scientists announced that a trial drug triggered an immune response in humans and shielded monkeys from infection.

Both participants and researchers were "blinded" to what they'd been given, which meant the results should not have been affected by people making decisions based on what they thought their vaccination status was.

Their trial of vaccine included the 400 healthy people and then their next level of study is going to include 2,600 women of South Africa which are said to be at risk of Infection of HIV.

During the initial stages of the drug testing, the researchers have found that the drug can trigger an immune response when administered to humans. In a world with HIV and AIDS is home to around 37 million people.

Based on the results from phase 1 and phase 2a clinical trials that involved almost 400 healthy adults in Rwanda, South Africa, Thailand, Uganda and the United States, a phase 2b trial has been initiated in southern Africa to determine the safety and efficacy of the HIV-1 vaccine candidate in 2,600 women at risk for acquiring HIV.

Eighth boy is 'pulled from Thai cave'
The operation began at around 11 a.m. local time on Monday and is expected to finish for the day around 9 p.m, reported the BBC . Rescue mission chief Narongsak Osottanakorn said it had resumed, with divers re-entering the cave at 11am local time (4pm NZT).

So far, a major limitation has been the lack of direct comparability between preclinical studies and clinical trials.

We don't yet know how well it will protect people from HIV-1 infections in real life. Known as APPROACH, the phase 1/2a trial tested seven different Ad26/Env HIV vaccine regimens for their safety, tolerability and the ability to elicit immune responses in 393 healthy adult volunteers in Rwanda, South Africa, Thailand, Uganda and the United States. Five participants reported at least one vaccine-related grade 3 adverse event, including abdominal pain, diarrhea, postural dizziness, back pain and malaise.

The same vaccine was also tested on rhesus monkeys and proved to be partially effective, protecting 67 percent of the test subjects from simian-human immunodeficiency virus, a virus similar to HIV.

They carried out parallel studies in rhesus monkeys and humans to define "the optimal vaccine regimen to advance into clinical efficacy trials".

In this study, the researchers aimed to evaluate mosaic adenovirus serotype 26-based HIV-1 vaccine candidates. It remains to be determined whether improved efficacy over RV144 will be achieved by either of the present efficacy trials (NCT02968849; NCT03060629). In early human trials the vaccine has been found to be safe in humans.

The aim of the study was to see whether the vaccine was safe, and whether people who received it still showed signs of the vaccine working after a year.

This study was funded by Janssen Vaccines & Prevention BV and the National Institutes of Health (OD024917, AI068618, AI078526, AI096040, AI124377, AI126603, AI128751, TR001102), the Ragon Institute of MGH, MIT and Harvard, and a cooperative agreement (W81XWH-07-2-0067) between the Henry M Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense.

Recommended:

  • Croatia can deal with Harry Kane after 'stopping Lionel Messi', says coach

    Croatia can deal with Harry Kane after 'stopping Lionel Messi', says coach

    A sweet moment of a little boy receiving his very own World Cup after completing cancer treatment is capturing hearts across the globe.
    June 2018 Jobs Report: Payrolls Pick Up

    June 2018 Jobs Report: Payrolls Pick Up

    The job growth wasn't enough to keep the unemployment rate from rising from 3.8 percent to 4 percent , the government said July 6. Some companies will likely respond to the tariffs by putting their hiring plans on hold until the trade picture becomes clearer.
    Women's top seed Simona Halep suffers shock defeat at Wimbledon

    Women's top seed Simona Halep suffers shock defeat at Wimbledon

    Asked when she thought she could win the match, Hsieh responded, "I don't feel I can", then leaned forward and laughed heartily. Bencic, now at 56 in the world, next faces two-time Grand Slam champion Angelique Kerber who swept past Naomi Osaka of Japan.
  • Maisie Williams posts on Instagram: 'Goodbye Game of Thrones'

    Maisie Williams posts on Instagram: 'Goodbye Game of Thrones'

    In early July, there was a " Game of Thrones " wrap party for season eight in Belfast. "Here's to the adventures to come". Game Of Thrones will return for season 8 in 2019.
    Wimbledon Won't Budge On FIFA World Cup 2018 Final Clash

    Wimbledon Won't Budge On FIFA World Cup 2018 Final Clash

    They also helped Fox hit new ratings highs for its coverage of this year's World Cup . The victor will face either France or Belgium in the final.
    Sonos files for an IPO

    Sonos files for an IPO

    Those 19m products are found in around 6.9m homes worldwide, Sonos says, and the immediate upshot is more music being played. The company did not specify how many shares would be for sale, nor did it list an estimated offering price.
  • North Korea Rejects Washington's 'Gangster-Like' Demands

    North Korea Rejects Washington's 'Gangster-Like' Demands

    "I have confidence that Kim Jong Un will honor the contract we signed &, even more importantly, our handshake", Trump wrote. She said the dinner lasted an hour and 45 minutes and at times the two were "cracking jokes" and "exchanging pleasantries".
    England fans trash an Ikea following win over Sweden

    England fans trash an Ikea following win over Sweden

    The trio have not clicked, and it has been a combination of set pieces and captain Harry Kane that have made the difference. Gareth Southgate was bursting with pride last night after England reached their first World Cup semi-final for 28 years .
    It's not coming home yet, England

    It's not coming home yet, England

    Despite reaching the semi-final, Southgate was keen to stress that his players were still developing. ENGLAND march into today's World Cup quarter-final against Sweden with the nation behind them.
  • Kylie Jenner says she is no longer using temporary lip fillers

    Fans of the 20-year-old cosmetics queen quickly noticed a big difference in her face in her recent Instagram photos . The "old Kylie " returned to social media Sunday as Jenner revealed that she removed her lip filler.
    German, NATO officials wary of Trump-Putin summit

    German, NATO officials wary of Trump-Putin summit

    Trump has noted that most allies are not meeting their commitment of spending 2 percent of gross domestic product on defense. On Putin's wish list: an end to USA military exercises in Europe and the scaling back of US forces there.
    Suzuki reveals European specs of new Jimny

    Suzuki reveals European specs of new Jimny

    The design principles are functional too, as this will still be a vehicle built specifically for tough terrain when it arrives. The Jimny's interior, meanwhile, gains modern features such as a 7-inch touchscreen infotainment system with Bluetooth.


Popular

Travis Pastrana lands Caesars Palace jump in Las Vegas
Performed live for the History Channel , Pastrana launched himself into the record books while honoring one of his heroes. After finishing with a few burnouts, Pastrana celebrated his triplicating feat by diving into the fountain.

US threatened nations over breastfeeding resolution
The State Department declined the Times' request to comment and said it could not discuss private diplomatic conversations. Health advocates had trouble finding another sponsor who did not fear USA "retaliation".

Starbucks to ban plastic straws within two years
For users who still want their drinks with a straw, the company said paper or biodegradable plastic will be available by request. Starbucks announced plans to eliminate more than 1 billion plastic straws per year from its stores worldwide by 2020.

Trump nears decision on replacement for Supreme Court
Falwell insisted only that Trump make his next selection from the list of prospective nominees he released before his election. He has not yet publicly indicated that he has narrowed the list and could still consider others in the mix.

Trump lawyer blasts Russian Federation probe as 'most corrupt' ever
Sources close to Cohen have slowly begun telling the media that the president's former attorney is ready to flip on his ex-boss. Bolduan asked if there's any signal that Cohen is now cooperating with prosecutors.

Josh Brolin Recreates Thanos' Infinity War Snap for Mass Reddit User Ban
Josh Brolin, the man behind the Infinity Gauntlet , ushered in the random banning in a short video of him snapping his fingers . Thanos saw this happen on his home planet of Titan and was cast out after suggesting genocide to ultimately save his world.

Mike Pompeo dismisses North Korea's 'gangster' comments, says talks are going well
But after two days of theatrical amity in Pyongyang it appeared to mark a return to the North's traditional hardline position. However, he did not go into detail about what was actually achieved during his latest stay in Pyongyang.

91-year-old woman killed when helicopter crashes into Williamsburg condo
Firefighters from James City County, Williamsburg and York County fought the blaze, which continued to smolder into the evening. The College of William and Mary said the incident happened near Dillard Complex and that people should avoid the area.

Pompeo brushes off North Korean 'gangster' claim
Many were surprised when Trump agreed at the summit in Singapore to end joint military exercises with South Korea. A letter from Kim to Trump was also delivered to Pompeo through Kim Yong-chol, a top North Korean party official.

Borat Star Sacha Baron Cohen Is Making a Trump University Movie Next
In the run up to the 2016 election, Cohen shot a sequence for The Brothers Grimsby involving then candidate Trump contracting HIV. Cohen has yet to confirm whether this means he is working on a movie about Trump , but it wouldn't be a surprise.