Ronaldo had the opportunity to stake his claim as the GOAT at the World Cup following Messi's elimination but he, too, is being sent home after Portugal lost 2-1 to Uruguay courtesy of a dazzling Edinson Cavani display.
Like Messi, Ronaldo has never scored in a knockout round match at the World Cup.
Uruguay's Edinson Cavani has scored three World Cup goals, one v Germany in 2010, one v Costa Rica in 2014 and one v Russian Federation in 2018.
The European champions will face Uruguay in Sochi for a place in the quarter-finals after finishing as runners-up behind Spain in Group B. "It's exciting. there are no words to describe this".
Portugal XI: Rui Patricio; Ricardo Pereira, Pepe, Jose Fonte, Raphael Guerreiro; Bernardo Silva, William Carvalho, Adrien Silva, Joao Mario; Goncalo Guedes, Cristiano Ronaldo. But with Uruguay sitting back, Portugal did equalise 10 minutes into the second half.
Pepe's goal was the first time the South Americans' defence had been breached in this tournament, but they stood firm after that and are beginning to look like genuine contenders moving into the latter stages in Russian Federation.
"But what he has on top of all those qualities, he's the leader of that team, and there is not one single player who can contain him".
While Suarez delivered for the South American side, Cristiano Ronaldo scored four of Portugal's five goals in the group stages.
Heroics from Cristiano Ronaldo, Lionel Messi, Hirving Lozano
Argentina's narrow win over Nigeria on Tuesday has set up a tie against France in the first knockout round of the World Cup . No Arab sides in the last 16 and Tunisia manager Nahib Maaloul is not convinced things will improve easily.
In reaching the Round of 16, Portugal have improved on their showing at the 2014 World Cup where they were eliminated at the group stages.
His first goal on Saturday involved an incredible, cross-field combination with Luis Suarez.
Suarez and Cavani combined brilliantly for the seventh-minute opener on Russia's Black Sea coast.
But parity did not last long, Cavani steering a brilliant curling finish into the corner after 62 minutes following Bentancur's beautifully-weighted pass into his path. KEYS TO THE GAME Stopping Ronaldo.
It was a five-pass buildup from deep in their own end that culminated in Uruguay's first goal, and the final two passes were ideal.
The Paris Saint-Germain striker, however, then limped out of the action - with Ronaldo helping him off the pitch - and was replaced after 74 minutes.
The marquee match will see two teams who repeatedly punch above their weight looking up to their celebrated talismen to deliver the goods and keep the entire bunch together using their reservoir of experience.
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